Loaiza is the only child of her parents. However, her mother had children from a previous marriage.

Karly-Marina Loaiza, known professionally as Kali Uchis was born on July 17, 1994, in Alexandria, Virginia, United States of America. Following her graduation, Uchis released her debut mixtape, Drunken Babble, on August 1, 2012.

In 2014, Kali Uchis collaborated with rapper Snoop Dogg on the song “On Edge” for his mixtape, That’s My Work 3.

On December 9, 2019, Kali Uchis was featured on the single “10%” by Canadian producer Kaytranada, which was taken from his album Bubba.

For her collaboration with Colombian musician Juanes,  Kali Uchis was nominated for a Latin Grammy Award for Record of the Year for “El Ratico” in October 2017.

“Telepatía” from Uchis’ second studio album debuted inside the top 10 of Billboard’s Hot Latin Songs chart, reaching the peak of the chart on the week of May 22, 2021.

“Telepatía” from Uchis’ second studio album reached number 3 on Spotify’s US Top 50 and number 2 on the service’s Global Top 50.