John Regala’s showbiz career stalled due to heavy drug abuse. Later, he went on to a drug rehabilitation centre and became a Christian minister. After some years of his life, he decided to become a member of the Iglesia ni Cristo. He later converted to Members Church of God International but went back to Iglesia ni Cristo in 2015.

Regala became an environmentalist and worked as the president and CEO of Project Green Evolution, Inc, which produces the Water Bonsai Organic Root Grower.

In August 2020, Regala was hospitalised for liver cirrhosis. He died at 6:05 am on the morning of June 3, 2023, from cardiac arrest brought on by liver and kidney complications as confirmed by his wife.

Regala was best known for his portrayals in: Alyas Baby Face, Primitivo Ebok Ala: Kalaban Mortal ni Baby Ama, The Vizconde Massacre: God, Help Us and Batas Ko ay Bala.