Ed Asner was best known for his character Lou Grant, who was first introduced on The Mary Tyler Moore Show in 1970.

In 2007, Ed Asner voiced the main villain Krad in Christmas Is Here Again. In 2009, he voiced Carl Fredricksen in Pixar’s animated film Up. As a voice actor, Ed Asner voiced Roland Daggett and Granny Goodness in the DC Animated Universe and J. Jonah Jameson in the 1994 Spider-Man series.

Ed Asner also voiced Napoleon in the Disney show W.I.T.C.H., and Kid Potato in the PBS Kids show hit WordGirl. He also provided the voice of famed American orator Edward Everett in the 2017 documentary film The Gettysburg Address.

Ed Asner provided the voice of the main protagonist Carl Fredricksen in the Academy Award-winning Pixar film Up (2009). Asner was the voice-over narrator for the 2016 documentary Behind the Fear: The Hidden Story of HIV, directed by Nicole Zwiren.

In 2001, Ed Asner was the recipient of the Screen Actors Guild Life Achievement Award. In 1996, Ed Asner was inducted into the Academy of Television Arts & Sciences Hall of Fame.